Internal Research -- Cellular Plasticity
Animal studies also have revealed that the basic wiring diagram of the brain emerges during development. Most connections (synapses) among neurons, however, are crude and non-functional. Subsequent experience is required to refine these synaptic connections, thereby fine tuning the functions of various circuits. Activity-dependent synaptic reorganization continues within the adult brain, as well (Figure 3). Learning a new experience initiates a neural activity, which ultimately produces synaptic reorganization among neurons in the relevant circuit. These synaptic changes (synaptic plasticity), distributed throughout the neural circuit, are considered to be the physical basis of long-term memory.